Endocarditis

Micro Organisms

Endocarditis

Duration

Duration as per type of infection

Native Valve Indolent (subacute)

Important: Therapy

Amoxicllin IV 2g four hourly
+

 Gentamicin (See synergistic gentamicin guidance)

Native Valve Severe sepsis (Acute)

Important: Therapy

Flucloxacillin IV 2g six hourly (four hourly if >85kg)

Prosthetic Valve or suspected MRSA

Important: Therapy

Vancomycin IV (dosing as per guideline)
+

 Gentamicin (See synergistic gentamicin guidance)

+
When therapeutic vancomycin levels reached add Rifampicin PO 600mg twice daily

 

Notes:

Always check for interactions with rifampicin.

Important: Notes

See national BSAC guidance for additional information (HERE)